The most comprehensive source of eukaryotic gene regulation data

Incorporating TRANSCompel™ and TRANSPro™ 

BKL TRANSFAC^® is an internationally unique knowledgebase containing data on transcription factors, their experimentally-proven binding sites, and regulated genes. Its broad compilation of binding sites allows the derivation of nucleotide distribution matrices, which can be used with the included tools to search DNA sequences for transcription factor binding sites.

A subscription to BKL TRANSFAC^® provides you with:

• Up-to-date transcription regulation details from the PubMed literature for more than 300 species, with a focus on human, mouse, rat, yeast, worm, and plant, and organized in a one-report-per-protein format

• Promoter reports including ChIP-chip/Seq based histone modification locations, transcription start sites, and single nucleotide polymorphisms (SNPs).

• ChIP reports that include the best scoring site prediction for the respective factor as well as downloadable sequences and gene lists.

• Binding site prediction ability with the Match™ tool, based on 1,300 positional weight matrices (PWMs) derived from experimentally verified data

• A pathway visualization tool for building custom networks out of experimentally demonstrated DNA binding and transcriptional regulation interactions

To learn more about this product, check out our statistics, user publications, sign up for a free trial, or contact a sales representative. 

Your Advantage

Leverage all the latest research on DNA binding, expression, and regulation in one resource:

• 37,000 Factor-site interactions

• 1,000,000 TF ChIP fragments

• 3,000,000 Histone modification locations

• 284,000 Promoter sequences

• 22,000 References

• 300 Species

Comprehensive data coverage

Save time on literature searches with up-to-date, manually curated, gene regulation data all in one place, including:

• Experimentally proven transcription factor binding sites & composite elements
• Positional weight matrices
• Promoter sequences containing TSSs, SNPs and other features
• miRNAs and their target sequences
• Extensive structural and functional information on transcription factors including our transcription factor classification

With optional inclusion of:

• Pathologically relevant mutations in transcription factors or their binding sites - PathoDB®
• Scaffold or matrix attached regions (S/MARs) of eukaryotic genomes and their binding proteins - S/MARt DB™

Advanced analysis tools

Use the experimental data in the included tools to

• Analyze DNA sequences for transcription factor binding sites using Match™ and Patch™, matrix and pattern based search tools
• Visualize gene-regulatory networks
• Find in-vivo binding sequences from ChIP on chip experiments
• Extend these capabilities with BIOBASE’s ExPlain™ analysis system.

To learn more about this product, check out our statistics, user publications, sign up for a free trial, or contact a sales representative.

BIOBASE products are available online or installed at your site.  To request information on installation system requirements, click here.

Learn more about different components of TRANSFAC, TRANSCompel™ and TRANSPro™ 

Learn about TRANSFAC Affymetrix GeneChip® Compatibility

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